Engineered aglycosylated full-length IgG Fc variants exhibiting improved FcγRIIIa binding and tumor cell clearance
نویسندگان
چکیده
منابع مشابه
Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors.
Immunoglobulin G plays a vital role in adaptive immunity and antibody-based therapy through engagement of its Fc region by the Fc gamma receptors (Fc gammaRs) on immune cells. In addition to specific protein-protein contacts, N-linked glycosylation of the IgG Fc has been thought to be essential for the recognition of Fc by Fc gammaR. This requirement for the N-linked glycan has limited biomanuf...
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ژورنال
عنوان ژورنال: mAbs
سال: 2017
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2017.1402995